Analysis of the literature shows that extraintestinal manifestations of IBD occur in 5-20% of cases and divided into three groups: 1. Independent of inflammatory activity in the intestine (joint damage (peripheral arthritis), skin (erythema nodosum, pyoderma gangrenosum), ocular (episcleritis, uveitis, iridocyclitis) and vascular (thrombosis, embolism). 2. Do not depend on the activity of inflammation in the intestines (the defeat of the joints (ankylosing spondylitis, rheumatoid arthritis, sacroiliitis), the lesions pankreatogepatobiliarnoy system (primary sclerosing cholangitis (PSC), holangiogennaya carcinoma, autoimmune hepatitis (AIH), autoimmune pancreatitis (AIP) and skin lesions (psoriasis). 3.
The consequences of malabsorption and of inflammation (steatohepatitis, cholelithiasis, chronic pancreatitis, chronic cholecystitis, osteoporosis, anemia, amyloidosis). Hepatobiliary system and IBD. Liver and biliary tract is common in NUC and BC. Data on the frequency of liver damage in IBD is largely dependent on the completeness of the survey. In 17-27% of patients with NUC and 38% of BC was observed increased activity of transaminases and alkaline phosphatase, as well as increase the level of bilirubin.
Histological examination of biopsy specimens of liver obtained from patients with IBD showed that 50-60% of those observed moderate changes (fatty infiltration). Severe liver damage occurs in less than 3% of patients. Primary sclerosing cholangitis. If there are areas of PSC narrowing intra and extrahepatic bile ducts with their prestenoticheskim extension. It is established that patients with PSC in 70-80% of cases also have IBD, and in 12-15% patients with IBD is detected PSC. The prevalence of PSC is 2-7 cases per 100 thousand population, with men affected 2 times more often than women. It is assumed that the increased permeability of the intestinal epithelium in NUC facilitates penetration of endotoxin and toxic bacterial products into the portal vein and then into the liver. Toxins can cause periangiocholitis, impaired excretion of bile and bile duct damage. Not exclude them enterohepatic circulation. In 80-85% of patients with PSC and in 30-80% of cases in patients with IBD revealed antineutrophil cytoplasmic antibody, which is possibly a reflection of general immune mechanisms.
Nowadays 30% of infertility is caused by disorders of the female, 30% – male disorders, 30% is the combined infertility. And 10% of the doctors can not find the cause of infertility. It is important to remember that among the factors cervix. Women who smoke the success of ART (helper reproductive technology) is much lower – their ovaries react poorly to ovulation stimulation. In men, nicotine leads to disruption of the educational process sperm. Drug abuse (marijuana, etc.) and medications that are prohibited by the uncontrolled admission, reduces the quantity and quality of sperm. In particular, alcohol lowers levels of testosterone – a hormone that plays an important role in the formation of sperm. In women, alcohol in large amounts interferes with the menstrual cycle and leads to the cessation of ovulation.
Alcohol also increases the likelihood of miscarriage and can cause birth defects in unborn babies. Nutrition is an important factor weight. A significant deviation from the norm – whether overweight or lack of it can lead to a reduction coffee consumption. You should also remember that fizzy drinks and chocolate contain caffeine. There is evidence that drinking a cup of coffee before intercourse can increase the activity of sperm. Folic acid acid found in green leaves of vegetables, lentils, asparagus, papaya, broccoli, liver, chicken and veal boiled eggs, wheat germ. Sport Despite the apparent benefit of maintaining good shape, excessive physical stress can negatively impact on men seeking to conceive. Increased body temperature in the scrotum, sperm quality deteriorates.
Environmental research has shown that in the recreation areas over the sea in the ozone layer dominates lactic acid bacillus. In environmentally disadvantaged areas are the opposite. And there, most people complain to the work of the digestive system. Today it is no secret that a good digestion depends on the microflora inhabiting the digestive tract. In cities is difficult not to feed your friends with bacterial products, preservatives, dyes, disintegrants, stabilizers and other chemicals, like antibiotics that kill bacteria so important. Man breathes the poisoned air, drinking bad water, drinking in general violate the regime and then transport medium slag output lags behind the general metabolism, etc. This is the main reason for the failure of adaptive mechanisms – IMMUNITY.
Start it is intestinal wall! The error of modern society is that by advertising convince us of the usefulness of yogurt, but …. they do not contain dairy sour sticks Mechnikov. Yes, they are useful as food, and if the period of storage is not more than 3 days. Analysis of the scientists showed that the "live bio yogurt" does not happen! In products with long shelf life can not live bacteria, the floor – the year, it just dies … why fermented milk market such a product does not have …. What do? How to raise immunity to propagate a number of important microorganisms. PRESENT MOVEMENT MECHNIKOVSKOE offers a technique called "Oseyanie." The method developed consciousness of the population in a new aspect – "the microbes to of man.
" Therefore, there is refreming conscious relation to its protective microflora. Personal health is the lot of man himself, rather than doctors. Top of the knowledge laid Ilya Ilyich Mechnikov. He always advocated preventive medicine. Although he received the Nobel Prize for developments in the field of immunology, namely, for the phagocytic theory of immunity, (incidentally, the last 100 years the prize of Russian scientists in the ARMY Physiology and Medicine).